the unfolded protein response, the accumulation of misfolded proteins in the ER

Question

the unfolded protein response, the accumulation of misfolded proteins in the ER serves as a signal for the cell to do which of the following?

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2

Macromolecules, such as proteins, travel between components of the endomembrane system by...

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3

Select all of proteins below that are made on the membrane-bound ribosomes of the rough ER?

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4

What portion of a polypeptide being synthesized determines which type of ribosome, free or bound, will complete its synthesis?

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5

All of the following are types of protein processing that can occur in the endoplasmic reticulum EXCEPT...

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6

Integral membrane proteins are inserted in the correct orientation in the membrane with the assistance of what protein of the endoplasmic reticulum?

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7
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The initial response of the cell to misfolded protein accumulation in the ER is _________. If that does not clear up the problem the cell will then initiate _________ and if that is not successful then the cell will initiate _______________.

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8

The process by which misfolded proteins in the ER are transported to the cytosol, labeled with ubiquitin and then degraded by proteosomes is called _______________.

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9

Translation is stopped in ____________.

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10
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11

What is the purpose of chaperones?

Explanation / Answer

1.(d)

In the unfolded protein response, the accumulation of misfolded proteins in the ER serves as a signal for the cell to produce more Chaperones.

2.(a)

Macromolecules, such as proteins, travel between components of the endomembrane system by Diffusion

3.

proteins below that are made on the membrane-bound ribosomes of the rough ER are ER Chaperones , Secreted proteins and receptors on plasma membrane

4. Signal recognition particle decides the type of ribosome to be used in synthesis

5. Phosphorylation is a type of protein processing that does not occur in ER

6.Integral membrane proteins are inserted in the correct orientation in the membrane with the assistance of Translocon protein of the ER

7. UPR , ERAD , Apoptosis

8.The process by which misfolded proteins in the ER are transported to the cytosol, labeled with ubiquitin and then degraded by proteosomes is called ERAD

9. Translation is stopped in the unfolded protein response

10. The c - terminus will be outside of the cell.

11. Purpose of Chaperones is they recognize and bind to unfolded or misfolded proteins and help them attain their native (i.e. correct) structure.

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