You will be using melting point to confirm the identity of the unknown drug in y

Question

You will be using melting point to confirm the identity of the unknown drug in your drug mixture. If you did not have melting point data, could IR spectroscopy be used to differentiate among the three possible unknown drug compounds? Explain why or why not. In a separation experiment using an aqueous solution and dichloromethane, which layer is on the bottom of the separatory funnel-the aqueous layer or the dichloromethane layer? What physical property allows you to determine this without doing the experiment in lab? Describe an experimental procedure that you could use to test whether or not a particular layer in a separatory funnel is aqueous. Why is acetone used to rinse the original beaker and to wash the solid compound on the Buchner funnel? In Step 5 of the Procedure section below, why are you adding calcium sulfate to the solution in the Component B flask? Write out the flow chart on p.2. Using the information in the Introduction and Procedure sections of this lab, identify the Components A B, and C, and determine what compounds should be in the boxes with question marks. Note that the answer to this question is NOT a replacement for the Procedure section of your lab report.

Explanation / Answer

Melting point of compound is fixed at standard condition. It can be also used to check the purity of a compound. In the case of IR the functional groups can be easily identified. So if the unknown drug is different from the other two drugs( not an isomer), then it can identified provided that we know the structure of the unknown. If similar functional groups are there, then it will be difficult.

3) Dichloromethane(DCM) will be in the bottom layer. Density of DCM (1.33g/ml) is greater than that of water(1g/ml). This will help to determine whether the bottom layer is DCM or water.

Add some water to the separating flask. If it is forming a distinct layer then there won't any aqueous layer. If the volume of any one of the layer is increasing, then that will be aqueous layer.

4) Due to limited solubility of the compound, it is used to wash away any other impurities which are soluble in acetone. Also water can be removed from beakers when rinsed with acetone. Acetone will break the extensive hydrogen bonding in water and help to make it volatile. Calcium sulfate act as dessicant( absorb water) and hence it can be used to dry compound.

5. Need information

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