Aldosterone is hydrophobic and acetylcholine is a charged molecule. Which of the

Question

Aldosterone is hydrophobic and acetylcholine is a charged molecule. Which of these is an intracellular signlaing molecule and why?

Aldosterone because it can pass through the lipid bilayer

Acetylcholine because it can pass through the lipid bilayer

Aldosterone because it binds direclty to the DNA

Acetylcholine because it binds directly to the DNA

Aldosterone because it can pass through the lipid bilayer

Acetylcholine because it can pass through the lipid bilayer

Aldosterone because it binds direclty to the DNA

Acetylcholine because it binds directly to the DNA

Explanation / Answer

Answer aldosterone because it can pass through the lipid bilayer.

Aldosterone is hydrophobic and can diffuse across the lipid bilayer, while acetylcholine is charged and cannot pass the lipid bilayer. For a signal molecule to bind with an intracellular receptor it must be able to pass through the cellular membrane. Generally signal molecules that enter the cell are nonpolar and fat soluble. These signal molecules can pass through the lipid bilayer of the cell membrane. Aldosterone is hydrobhopic means non polar and fat soluble. So, act as intracellular signal molecule and can pass through lipid bilayer.

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