Tetrodotoxin is a well-known highly potent neurotoxin that blocks the function o

Question

Tetrodotoxin is a well-known highly potent neurotoxin that blocks the function of voltage gated sodium channels, a) Describe two possible binding interactions of the molecule with the target given the structure, b) Despite tetrodotoxin being a potent neurotoxin, victims are fully conscious during poisoning. Explain this phenomenon using a molecular argument. Several pharmaceutical drugs contain the trifluoromethyl (-CF_3) functional group. An example is the commonly prescribed anti-depressant drug fluoxetine. Enumerate two reasons for introducing a trifluoromethyl group in a drug molecule.

Explanation / Answer

1)

Tetrodotoxin blocks the blocks the function of voltage gated sodium channels. There are two possible binding interactions well discussed though.

b) Even though tetrodotoxin is very potent neurotoxin, it acts on central nervous system.

      It cannot pass through Blood Brain Barrier. Therefore, victims stay awake during poisoning.

2)

Fluorine atom has dramatic effect on medicine molecules properties.

  

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