Mutations in genes involved in the secretion process result in the accumulation

Question

Mutations in genes involved in the secretion process result in the accumulation of secreted proteins in specific cellular compartments. Assume that protein X is a secreted protein and that the gene encoding protein X is being actively transcribed. Where in the cell would protein X accumulate in cells with the following homozygous mutations?

Loss of function mutation of the signal recognition particle (SRP) gene.

Loss of function mutation of the signal peptidase gene.

Loss of function mutation in COPII subunit gene

Loss of function mutation in the V-snare gene

Explanation / Answer

1. Endoplasmic Reticulum in eukaryotes and the plasma membrane in prokaryotes

2. Plasma membrane of endoplasmic reticulum.

3. Endoplasmic Reticulum-Golgi Interface.

4. Trans-Golgi network and the vacuole

Related Questions

Navigate

• Browse (All)
• Browse M
• Subjects

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.