Mutations in genes sometimes result in problems with metabolic regulation. a. Do
ID: 40368 • Letter: M
Question
Mutations in genes sometimes result in problems with metabolic regulation.a. Do mutations always result in loss of protein function? Explain.
b. Using phosphorylation as an example, describe the possible effect of single amino acid mutation (one amino acid is different between the normal and mutated proteins) on covalent regulation of metabolism. As part of your answer, state your assumptions about identity of the amino acids under normal conditions and in a call expressing the mutant protein.
c. Describe the effect of a single amino acid mutation on allosteric regulation of metabolism.
Mutations in genes sometimes result in problems with metabolic regulation.
a. Do mutations always result in loss of protein function? Explain.
b. Using phosphorylation as an example, describe the possible effect of single amino acid mutation (one amino acid is different between the normal and mutated proteins) on covalent regulation of metabolism. As part of your answer, state your assumptions about identity of the amino acids under normal conditions and in a call expressing the mutant protein.
c. Describe the effect of a single amino acid mutation on allosteric regulation of metabolism.
Mutations in genes sometimes result in problems with metabolic regulation.
a. Do mutations always result in loss of protein function? Explain.
b. Using phosphorylation as an example, describe the possible effect of single amino acid mutation (one amino acid is different between the normal and mutated proteins) on covalent regulation of metabolism. As part of your answer, state your assumptions about identity of the amino acids under normal conditions and in a call expressing the mutant protein.
c. Describe the effect of a single amino acid mutation on allosteric regulation of metabolism.
Explanation / Answer
1. Loss of protein function happens only if a mutatin happens in the gene coding for any protein- there are coding and non coding sequences in a genome, they are called exons and introns respectively. if a mutation happens in the intron region of a genome, then there will be no evident mutation seen.
2. prosphorylatin is the addition of phosphate group to a nornal protein. this phosphorylation thus changes the original structure of the protein, in turn changing its function and location (target site) as well.
3. allosteric effect is the effect of change in one protein on another protein at a different site. this is very specific, there will be no cross reactions, bt when a mutation happens in a coding sequence of one allosteric protein, it codes for a different, mutated protein or might not code anything at all. thus it also affects the other protein that it usually is an effector for.
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