The epigenetic down-regulation of genes is emerging as a possible underlying mec

Question

The epigenetic down-regulation of genes is emerging as a possible underlying mechanism of
the GABAergic neuron dysfunction in schizophrenia. For example, evidence has been
presented to show that the promoters associated with reelin and GAD67 genes are downregulated
as a consequence of DNA methyltransferase (DNMT)-mediated hypermethylation.
Reelin is up-regulated by the binding of the T-box transcription factor -1 (Tbr-1) binding to its
promoter region. GAD67 can be up-regulated by SDF1?, a transcription factor, binding to
GAD67

Explanation / Answer

A. Using neuronal progenitor cells to study this regulation, design an experiment that would test
this hypothesis. Be specific

neuronal progenitor cell are derived from patients skin cells and are used for the study of schinophernia, the mi RNA plays a very imporatnat role in the neuronal disease by modulating the diffrent embryonic neuronal fate .MiR137 ,plays a very important role in the regulating the embryonic stem cell proliferation , fate determination, neuronal proliferation , differentiation, synaptic maturation. the   dysregulation of the gene expression , effects the nervous system   leading to mental disorders , so epigenetic regulation of Mi R 137 leads to the proper functioning of the neuronal stem cells there by preventing the disease . the methylation of the MiR137 affects the expression of the Mi R 137, so by taking these experimental condition , we concstruct experiment showing

embroyonic stem cells were taken , and Mi R137 expression is regulated by the two egnes one is tlx D , gene which is a transcription factor , and other is histone demthylase ldx1 , the binding of the tlx gene and ladx leads to the expression of the M i137 , . t the epigenetic regulation invloves the two genes sox 2, and ehz2 , binding of these genes regulate the production of levels of mi137 gene. mecp2 is the reprssor molecule of the miR 137 gene .

so theregulation of mecp2 and sox2 to promoter causes the epigentic rgulation of    by producing the ehz2 gene which further binds to the chromatin region , so the methylation of the sox 2 or the mecp2 causes the over expression of the miR 137 , this is what happens inthe shcizopherna patients

these findings support the development of epigenetic drugs as a potential novel therapeutic strategy to alleviate deficits associated with schizophrenia?

yes these findings are ver helpful in the drug targeting , because by preveting the methylation process in the promoter region of the sox2 or mecp2 gene   leading to the normal epigentic control of the Mir137 , produces the normal ehz2 gene which then bind to chromatin region on the DNA leading to the epigentic regulation

the attached image shows the overall regulatory factors involving the gene regulation of Mi 137 gene in neuronal stem cell

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