Looking at the first Germ-Line h-chain DNA only, assume Dh1 joins Jh2. How many

Question

Looking at the first Germ-Line h-chain DNA only, assume Dh1 joins Jh2. How many other D segments would remain? How many other J segments would remain?

LVH1 LVHn DH1 DH7 DH13 Germ-line H-chain DNA D-J joining LVH1 LVH21 LVHn DH1DH6DHH V-DJ joining Rearranged LVH1 LVH20 L V DJ J,H H-chain 5' DNA Transcription L V DJ Primary RNA transcript Polyadenylation RNA splicing mRNA (A) or Translation Translation L V DJ C Nascent polypeptide or V DJ C or heavy chain heavy chain Figure 5-5 Kuby IMMUNOLOGY, Sixth Edition © 2007 W. H. Freeman and Company

Explanation / Answer

If Dh1 joins Jh2, then all Dh segments after Dh1 will get deleted. And since there are 4 Jh segments, joining to Jh2 will cause Jh3 and Jh4 to be left.

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