The neural tube is patterned along the dorsal-ventral axis by opposing morphogen

Question

The neural tube is patterned along the dorsal-ventral axis by opposing morphogen gradients. What is the phenotype that would be produced by the following manipulations? In each case explain your answer in the context of the proposed dorsal-ventral mechanism and provide a molecular technique that would allow you to asses the cell fates.

a. The notochord is transplanted from the ventral floor plate to the lateral side between the neural tube and the somites.

b.An embryo where Smad1 and 5 are knocked out in the dorsal neural tube right after the neural tube closes and splits off from the epidermal cells.

c. An embryo everexpressing a transcriptionally active form of Ci/Gli throughout the neural tube.

Explanation / Answer

control of cell fate has both deterministic and stochastic elements: complex underlying regulatory networks define stable molecular

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