Molecular Genetics Help Please: In the following figure, the meiosis in the fath

Question

Molecular Genetics Help Please:

In the following figure, the meiosis in the father (II-1) is informative with respect to the disease and locus B for which of his children?

a) None of the meioses are informative.

b) All of the meiosese are informative.

c) The meioses leading to two of the children (III-1 and III-4) are informative. The meioses for the other three children (III-2, III-3 and III-5) are all uninformative.

d) The meioses leading to three of the children (III-2, III-3 and III-5) are informative. The meioses for III-1 and III-4 are both uninformative.

e) The meioses leading to four of the children (III-1, III-3, III-4 and III-5) are informative. The meioses for III-2 is uninformative.

Molecular Genetics Help Please: The genotypes are: In the following figure, the meiosis in the father (II-1) is informative with respect to the disease and locus B for which of his children? a) None of the meioses are informative. b) All of the meiosese are informative. c) The meioses leading to two of the children (III-1 and III-4) are informative. The meioses for the other three children (III-2, III-3 and III-5) are all uninformative. d) The meioses leading to three of the children (III-2, III-3 and III-5) are informative. The meioses for III-1 and III-4 are both uninformative. e) The meioses leading to four of the children (III-1, III-3, III-4 and III-5) are informative. The meioses for III-2 is uninformative.

Explanation / Answer

(e) III-1, III-3, III-4 and III-5 are informative.

In pedigree analysis:

Dark square is affected male

therefore, dark circle is affected female

normal circle is normal female but in the third generation it she can be carrer; thus is informative.

normal square is a normal male since he has only one X-chromosome therefore chances of being a carrer is nullified.

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