2. For each of the following situations, what do you predict to be the mechanism

Question

2. For each of the following situations, what do you predict to be the mechanism of action of the tested drug/compound based on our discussions of RNA synthesis (i.e. what do you predict to be the cellular target of the drug).

a) In bacterial cells, compound X led to the formation of ~10 nucleotide RNA fragments, but larger mRNA expression levels dropped considerably.

b) In bacterial cells, compound Y led to the overexpression of genes related to vitamin B12 biosynthesis.

c) In bacterial cells, compound Z yielded longer transcripts as compared to a control.

Explanation / Answer

a) The RNA synthesized is to produce the small peptide chain to act against the drug.

b) The overexpression of genes could be due to the blocking of the molecules or proteins associated with normal signal transduction mechnism in the cell due to the action of drugs, leading to over expression of genes.

c) The longer polypeptide is synthesized from the mRNA,due to the drug or compound.

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