Protein cargo is folded during import and export to and from the nucleus (to cyt

Question

Protein cargo is folded during import and export to and from the nucleus (to cytosol). a. What does this mean for the location of the NLS/NES in the protein? b. Therefore, what ways could a cell regulate or alter the localization of a nuclear protein (like a What other proteins would need to be imported into the nucleus AND subsequently expor (Hint once in the nucleus they would assemble with nucleic acid) Which sequence could serve as an ER targeting signal sequence? NH2-Met-Leu-Ser-Leu-Arg-Gln-Ser-Ile-Arg-Phe-Phe-Lys-Pro-Ala-Thr-Arg- -Pro-Pro-Lys-Lys-Lys-Arg-Val-- NH2-Met-Lys-Ser-Leu-Leu-Val-leu-Gly-Ala-Ile-Leu-Phe-Trp-Ala-leu-Thr-Glu-Ala- --Ser-Lys-Leu-COOH In order for the SRP to do its job which include several functions, how many critical pr nding) sites do you think it has?

Explanation / Answer

1)

a) The location of the NLS in the protein means “Nuclear localization signal.” The location of the NES in the protein means “Nuclear export signal.” The NLS used for importing of protein from the cytosol to nucleus, whereas the NES used for exporting protein from nucleus to cytosol.

b) A cell can regulate or alter the localization of a nuclear protein in several ways like Ubiquitination, Phosphorylation and several other secondary modifications of proteins.

c) The other proteins that are required for protein nuclear import complex are:

The other proteins that are required for protein nuclear export complex are:

2)

An ER Targeting signal sequence is option (b).

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