b) These carboxylated Glu residues (called a Gla domain) bind to the anionic pho
ID: 37391 • Letter: B
Question
b) These carboxylated Glu residues (called a Gla domain) bind to the anionic phospholipid, phosphatidylserine via a chelated Ca2^+ ion. Edit the image below to show a Gla domain bound to the head group of phosphatidylserine. I have provided the amino acid backbone of the Gla domain, the Ca^+2, and the phosphate of the glycerophospholipid for you to build from. The first bond from the phosphate to the head group is drawn for you to get you started. Since Sapling does not have a way to draw dashed lines for non-covalent interactions, make sure that the atoms chelating the Ca are within 1 square-length away. c) Using Figure 6.40 from your text book, predict what will happen to the levels of thrombin in a patient takin? warfarin. In the box below, answer whether the thrombin levels will increase or decrease.Explanation / Answer
Anticoagulants like warfarin are used to treat and prevent blood clots that may occur in blood vessels. Warfarin is comparatively safer and the most commonly used anticoagulant. However, newer anticoagulants are now available and are likely to be used more and more. If warfarin is administered, then the patient needs to have regular blood tests to monitor how quickly the blood clots.
The main possible side-effect of anticoagulants is continous bleeding if injured or bruised as the thrombin levels or the the clotting factors are reduced thus the thrombin levels drop and does not form a clot and stop bleeding. Warfarin interacts with some medicines and foods too. So whenever warfarin is prescribed it is very important to tell the doctor, nurse or pharmacist what you are taking as an anticoagulant.
Anticoagulants are used to treat and prevent blood clots that may occur in your blood vessels. Blood clots can block an artery or a vein (blood vessels). A blocked artery stops blood and oxygen from getting to a part of your body (for example, to a part of the heart, brain or lungs). The tissue supplied by a blocked artery becomes damaged, or dies, and this results in serious problems such as a stroke or heart attack. A blood clot in a large vein, such as a deep vein thrombosis (a clot in the leg vein), can lead to serious problems such as a pulmonary embolism (a clot that travels from the leg vein to the lungs).
A number of anticoagulants are available including: warfarin, acenocoumarol, phenindione, dabigatran, apixaban and rivaroxaban. All come in various different brand names. Warfarin, acenocoumarol and phenindione are older types of anticoagulants and have been used for many years in the UK. Dabigatran, apixaban and rivaroxaban are newer types of anticoagulant.
Related Questions
Navigate
Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.