Which of the following statements about missense mutations are TRUE? Check all t

Question

Which of the following statements about missense mutations are TRUE? Check all that apply.

Missense mutations must occur in the DNA that corresponds to the open reading frame in the RNA (the part of the RNA that encodes the protein - between teh start and stop codons).

Missense mutations can change the shape and therfore function of a protein.

Missense mutations will change the length of the protein produced from a gene.

Missense mutations can either be gain-of-function or loss-of-function mutations

Missense mutations can occur anywhere in the RNA cododing region of a gene (including DNA that corresponds to the 5' and 3' UTR).

Explanation / Answer

Following statements are true for missense mutations:

a) Missense mutations must occur in the DNA that corresponds to the open reading frame in the RNA (the part of the RNA that encodes the protein - between the start and stop codons).

b) Missense mutations can change the shape and therfore function of a protein.

d) Missense mutations can either be gain-of-function or loss-of-function mutations

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