A loss-of-function mutation in which of the following would inhibit TGF? signali
ID: 35241 • Letter: A
Question
A loss-of-function mutation in which of the following would inhibit TGF? signaling? Select any/all answers that apply.
A.
I-Smad
B.
R-Smad
C.
Smad4
D.
Ski
E.
SnoN
2. Predict the consequences of a temperature sensitive mutation in which the phosphorylation of the ?-catenin protein is blocked. Above the permissive temperature:
A.
?-catenin levels will increase and ?-catenin will be constitutively active.
B.
?-catenin levels will increase and ?-catenin will be inactive.
C.
?-catenin levels will decrease and ?-catenin will be constitutively active.
D.
?-catenin levels will decrease and ?-catenin will be inactive.
E.
?-catenin levels will remain constant but cells will be unresponsive to Wnt signaling.
3. Which of the following are seven-transmembrane-domain serpentine proteins? Select any/all answers that apply.
A.
TGF?-receptor II
B.
LRP
C.
Frizzled
D.
Patched
E.
Smoothened
4. In the NF?B signaling pathway, which of the following molecules is downstream of I?B kinase? Select any/all answers that apply.
A.
NF?B
B.
TNF?
C.
TAK1
D.
IL-1
E.
Hedgehog
5. Which of the following is cleaved by regulated intramembrane proteolysis (RIP)? Select any/all answers that apply.
A.
Smoothened
B.
TNF?-receptor
C.
Delta
D.
Notch
E.
SREBP
A.
I-Smad
B.
R-Smad
C.
Smad4
D.
Ski
E.
SnoN
Explanation / Answer
I Smad , option A.
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