Timothy had a stroke and survived with no apparently physical consequences. Howe

Question

Timothy had a stroke and survived with no apparently physical consequences. However, he had been experiencing the symptoms a,b,c, below:

a. weight gain and fatigue

b. muscle weakness and atrophy

c. reproductive disturbances

After BLOOD tests, his physician told him he was deficient in several hormones and that was related to the stroke.

Based on what you have learned in the last lectures on endocrine system and in LAB CLINICAL ENDOCRINE SLIDES in particular     

For each of the Symptom , a,b c listed HOW IS THE STROKE related to it : for each a,b,c name the hormone or hormone issue associated with it and the stroke

Explanation / Answer

a) Thyroid glands and metabolism.under secreation leads to hypothyroidism (decreased appetite, increased wight gain,decreased heart rate, fatigue,impaired memory).

Hypothyroidism is associated with an elevated serum cholesterol level,atherosclerosis, coronary atrery disease, and poor left ventricular function all leads to stroke.

b) Hypofunctioning of the adrenal cortex.When aldosterone and cortisol blood levels low,A patients experiences generalized malaise,weakness,muscle atrophy and severe loss of fluids and electrolytes.Insufficient supply of cortisol signals the pituitary to secrete more ACTH which increses pigmentation of scars,skin folds and breast nipple

1)lack of specific influence of one or more cortical hormones directly upon the myocardium

2)Hemo-concentration

3)Low blood volume and perhaps consequent poor coronary flow

4)Poor alimentation and exhausted glycogen reserves

5)Disturbance in electolyele balance

The usual circulatory collapse in Addison's crisis is characterized by extreme dehydration and falling bllod pressure.The changes in electrolytes reflected in the serum reveal sodium,chloride and high potassium

c)The risk of heart disease and stroke increases with estrogen reduction

When estrogen levels decline,levels of LDL cholesterol increase,and levels of LDL cholesterol decrease,leading to the buildup of fat and cholesterol in the arteries that contributes to heart and stoke.

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