22. The extrinsic pathway of coagulation is initiated by the: a. sticking of pla

Question

22. The extrinsic pathway of coagulation is initiated by the: a. sticking of platelets to damaged tissue b. activation of Factor VII exposed to collagen c. release of tissue factor (Factor III) by damaged endothelium d. release of heparin by the liver e. conversion of prothrombin to thrombin 23. The common pathway of coagulation begins with: a. activation of a proenzyme exposed to collagen b. sticking of platelets to damaged tissue c. release of heparin from liver d. conversion of Factor X to prothrombin activator (prothrombinase) e. conversion of fibrinogen to fibrin 24. Most of the protein factors required for clotting are synthesized by: a. platelets b. liver c. kidney d. megakaryocytes e. spleen 25. The function of transferrin is to: a. b. c. d. e. help white blood cells emigrate from blood vessels carry iron ions in the bloodstream convert fibrinogen to fibrin promote differentiation of blast cells in bone marrow store iron in the spleen or liver 26. The primary organs whose macrophages are responsible for phagocytizing worn-out RBCs are the: a. spleen and liver b. spleen and kidneys c. liver and kidneys d. lungs and liver e. lungs and kidneys 27. How would the removal of calcium ions from a blood sample affect coagulation? a. the coagulation pathway would be lacking a required cofactor at man steps b. coagulation would be accelerated c. no important effect because magnesium can substitute for calcium d. would reduce thrombopoiesis e. increase the production of Factor XIII

Explanation / Answer

Answer 22

c. release of tissue factor (Factor III) by damaged endothelium.

Because Tissue factor serves as a cofactor with factor III to facilitate the activation of factor X.

Answer 23

d. Conversion of Factor X, to prothrombin activator.

Because the release of tissue factor VII

Answer 24

b. Liver

Because the proteins synthesized by the liver are- coagulation factors I (fibrinogen), II (prothrombin), V, VII, VIII, IX, X, XI, XIII,

Answer25

b. Carry iron ions in the bloodstream

Because for the absorption of iron in all the tiisue and organs

Answer 26

a.Spleen and liver

Because they are diffusely scatter in the connective tissue , spleen , liver and cns

Answer27

a.The coagulation pathway would be lacking a required cofactor at many steps

Because coagulation would be prevented.

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