Please read this article: de Langhe E, Vande Velde G, Hostens J, et al. Quantifi

Question

Please read this article:

de Langhe E, Vande Velde G, Hostens J, et al. Quantification of lung fibrosis and emphysema in mice using automated micro-computed tomography. PLoS ONE. 2012;7:e43123. https://doi.org/10.1371/journal.pone.0043123

This article details a method of measuring lung volumes in disease states, using computerized tomography (similar to a CAT scan). Consider the following questions: why is the measurement of lung volume important to the diagnosis of both emphysema and lung fibrosis? Why is the measurement of collagen (hydroxyproline content) important in determining disease states in the lung? How would collagen content differ in fibrosis and emphysema? Finally, why do you think the authors needed to perform histologic examination of the lung tissue they had measured when the animals were alive?

Explanation / Answer

Lung volume measurement is necessary to diagnose diseases as depending on the type of disease the lung volume varies.

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