1.Review Transplan rejection: In acute allograft rejection, this is noticed over
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Question
1.Review Transplan rejection: In acute allograft rejection, this is noticed over what time frame? How is it diagnosed? What is the recipient immune system recognizing on the donor cell? How is this type of rejection avoid? Name one medication used to prevent rejection___.
2.Even if acute allograft rejection is never a problem, there is a potential for chronic rejection: In chronic rejection, this is noticed over what time frame? What changes are seen in the patient? How is this type of rejection mediated? What is a risk factor for chronic rejection?
Explanation / Answer
Acute allograft:
Time frame: This rejection begins as early as one week after transplant. But the risk is highest in the first three months, though it can happen months to years.
Diagnosis: This rejection can be diagnosed based on clinical data, patient signs and symptoms, also on blood or even tissue biopsy.
Histological signs: (a) infiltrating T cells, (b) structural compromise of tissue anatomy (c) injury to blood vessels.
Immunity response: Process of acute rejection is mediated by the cell-mediated pathway, specifically by mononuclear macrophages and T-lymphocytes.
Anti-rejection medication : Immunosuppressants, By weakening or reducing your immune system's responses to foreign material, these drugs reduce your immune system's ability to reject a transplanted organ.
Treatment: Immunosuppressive drugs, examples: Cortosteroids.
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