You work for a pharmaceutical company where you are assigned the task of creatin

Question

You work for a pharmaceutical company where you are assigned the task of creating new drug therapies to treat thyroid disorders such as hyperthyroidism (high levels of T3 and T4) and hypothyroidism (low levels of T3 and T4). Your team has designed a few drugs, and your job is to identify which drug(s) would be successful in treating thyroid disorders based on your knowledge of thyroid hormone synthesis. Below is the list of drugs your team designed (all of these are hypothetical drugs). Peroxidine: A drug that inhibits thyroid peroxidase from functioning Cimigine: A drug that inhibits potassium/iodine cotransporter Iodimine: A drug that inhibits iodinase from functioning Aldosine: A drug that inhibits production of angiotensinogen from the liver Aldoramine: A drug that inhibits sodium/iodine cotransporter Thyromine: A drug that stimulates thyroglobulin production Identify the drug(s) that would be successful in treating hyperthyroidism and hypothyroidism, and explain why and how they would be successful.

Explanation / Answer

Drugs for hypothyroidism

Thyromine.

As thyroglobulin helps in the synthesis of thyroid hormones( T3,T4).

Drugs for hyperthyroidism

Aldoramine

Sodium/ iodine cotransporter mediate uptake of iodine into follicular cells which is the first step in thyroid hormone synthesis.

Peroxidine.

Thyroid peroxidase converts iodide available in the follicular cells into atomic iodine which is a step involved in hormone production.

If iodinase and thyroid peroxidase are the same then iodimine also comes under this.

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