You work for a pharmaceutical company where you are assigned the task of creatin

Question

You work for a pharmaceutical company where you are assigned the task of creating new drug therapies to treat thyroid disorders such as hyperthyroidism (high levels of T3 and T4) and hypothyroidism (low levels of T3 and T4). Your team has designed a few drugs, and your job is to identify which drug(s) would be successful in treating thyroid disorders based on your knowledge of thyroid hormone synthesis. Below is the list of drugs your team designed (all of these are hypothetical drugs).

Peroxidine: A drug that inhibits thyroid peroxidase from functioning

Cimigine: A drug that inhibits potassium/iodine cotransporter

Iodimine: A drug that inhibits iodinase from functioning

Aldosine: A drug that inhibits production of angiotensinogen from the liver

Aldoramine: A drug that inhibits sodium/iodine cotransporter

Thyromine: A drug that stimulates thyroglobulin production

Identify the drug(s) that would be successful in treating hyperthyroidism and hypothyroidism, and explain why and how they would be successful.

Explanation / Answer

Drugs for hyperthyroidism;

Peroxidine,cimigine,iodimine,aldoramine and aldosine

As iodine uptake ,synthesis and release will be inhibited,they are used for treatment of hyperthyroidism

Drugs used in hypothyroidism;

Thyromine,since it is a storage form and inactive in nature .Hence,can be used in hypothyroidism.

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