T-Cell Receptor vs. Immunoglobulins. Which of the following statements are true

Question

T-Cell Receptor vs. Immunoglobulins. Which of the following statements are true and which are false. I am really not sure where to start.

1. Both of them have 2 antigen-binding sites. 2. Both of them naturally occur in membrane-bound and secreted forms 3. Three CDRs of the v, TCR domain and 3 CDRs of the Vß TCR domain are analogous to the CDRs of the VH and V domains 4. The TCR resembles the membrane-bound Fab fragment of immunoglobulin: an antigen-binding site two variable domains, two constant domains 5. Both of them undergo somatic hypermutation. 6. Both of them are generated through somatic recombination of sets of gene segments. 7. The constant regions of both of them have similar functions. 8. Both the T-cell repertoire and the B-cell repertoire are generated by the same molecular mechanisms (combining different gene segments, junctional diversity, etc.). 9. Similar to the variable regions of the heavy chain of the B-cell Ig receptor, TCR variable genes are all encoded in three segments.

Explanation / Answer

1. False.

Ig's posses 2 binding sites for antigen, where as T cell posses only one binding site.

2. False.

T cells are only secreted forms .

3. True

4. True

5. False

6. True

7. False

8. True

9. True

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