1. A doctor measures your GFR to determine if you have normal kidney function. H
ID: 3516930 • Letter: 1
Question
1. A doctor measures your GFR to determine if you have normal kidney function. He uses inulin as a marker, injects it into your blood stream and after 30 minutes asks for a urine and blood sample. The doctor informs you that you have produced 90 ml of urine containing 30 mg of inulin/ml. Your blood sample contains 0.5 mg of inulin per ml. Use the following equation to determine if you have a normal GFR. U concentration of inulin in urine (mg/ml) V rate of urine production (ml/min) P concentration of inulin in the blood plasma (mg/ml) n the kidney lab the students who are given the salt load consume eight salt tablets with 452 mg NaCl/tablet. After the lab several students go to Burger king and each order the meal shown in the table. Compare the sodium intake between the lab class and the meal. Remember that 452 mg NaCl is not the same as 452 mg Na. 2, i Sodium content (mg) Food item Whopper with 1450 cheese Large fries Apple pie Large chocolate 640 880 270 shake Total sodiumExplanation / Answer
1. U= concentration of insulin in urine = 30 mg/ml
V= rate of urine production = 90 ml in 30 minutes.
Hence in 1 minute, V = 90/30 = 3 ml/ min
P= concentration of insulin in blood plasma = 0.5 mg/ml
Glomerular Filtration Rate= U×V/P = 30×3/0.5 = 180 ml/min
Normal GFR = 90 to 120 ml/ min
The GFR is higher than the normal Glomerular Filtration Rate.
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