5 question 5 (15 point You have developed a novel non-degradable biomaterial for

Question

5 question 5 (15 point You have developed a novel non-degradable biomaterial for controlled drug releaso. In it experiments on a thin slab (20 mm x 10 mm x 2 mm) showed that yo orofile shown below (solid line) with linear release over -30 days. Following imp however, the release rate into the surrounding tissue was dashed line) and zero release occurred after 12 days. s two parts to this question). ur material has the release implantation in vivo, severely decreased within the first 4 days 120 100 ? 80 D 40 0r 2 20 15 20 25 30 0 5 10 Time (days) a. (5 points) What is the most likely explanation for the difference between the in vitro and in v release rates? (5-8 sentences or less) - please write clearly, no scribbling

Explanation / Answer

The difference between in vitro and in vivo release rate of drug is due to non degradable biomaterial used. During in vitro drug delivery on thin slab this non degradable biomaterial is unaffected by other chemicals or enzyme due to controlled nature. But in case of in vivo drug delivery, this non degradable biomaterial is affected by many chemicals and enzymes of the body and undergoes some changes that prevent release of drug in due course of time. That's why the graph of in vivo release of drugs shows zero release after 12 days.

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