Which of the statements below best describes high affinity interactions between

Question

Which of the statements below best describes high affinity interactions between a neutrophil and endothelial cell? O ICAM-1 on leukocytes binds to LFA-1 on endothelial cells, acting as a "brake" to slow leukocytes down against blood flow. O ICAM-1 on endothelial cells binds to LFA-1 on leukocytes, acting as a "brake" to slow leukocytes down against blood flow. O ICAM-1 on leukocytes binds to LFA-1 on endothelial cells to mediate stable arrest. ICAM-1 on endothelial cells binds to LFA-1 on leukocytes to mediate stable arrest.

Explanation / Answer

d) ICAM -1 on endothelial cells binds to LFA-1 on leukocytes to mediate stable arrest.

ICAM -1 is an intercellular adhesion molecules that are present on endothelial cells. These bind to LFA-1 on leukocytes which are responsible for aggravating the disease. This binding brings about a stable arrest which prevents action of leukocytes on infected cells.

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