Mrs. Jones damaged her renal filtration membrane and lost the negative charge of

Question

Mrs. Jones damaged her renal filtration membrane and lost the negative charge of the basal lamina. What would be the consequence of this situation?

Question 4 options:

More proteins would get filtered and colloid osmotic pressure of the glomerulus would increase.

More proteins would get filtered and hydrostatic pressure in the glomerulus would increase.

Less proteins would get filtered and colloid osmotic pressure of the Bowman's capsule would increase.

More proteins would get filtered and colloid osmotic pressure of the Bowman's capsule would increase.

More proteins would get filtered and colloid osmotic pressure of the glomerulus would increase.

More proteins would get filtered and hydrostatic pressure in the glomerulus would increase.

Less proteins would get filtered and colloid osmotic pressure of the Bowman's capsule would increase.

More proteins would get filtered and colloid osmotic pressure of the Bowman's capsule would increase.

Explanation / Answer

Option 1st is correct answer. Basal lamina is composed primarily of negatively charged glycoproteins. Most plasma proteins have a net negative charge, they are repelled by the negatively charged glycoproteins of the basal lamina. Thus, damaging of renal filtration membrane and loss of the negative charge of the basal lamina increases the filtration of proteins. The plasma proteins causes colloid osmotic pressure in glomerulus and change in concentration of plasma protein can change the colloid osmotic pressure in glomerulus.

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