Lake Apopka, FL, early 1990s: after sunset, sometime in the spring. The eye-shin
ID: 3511200 • Letter: L
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Lake Apopka, FL, early 1990s: after sunset, sometime in the spring. The eye-shine from the gators was visible from quite a distance. Thank goodness that Dr. Guillette had recruited a bunch of football players to work on his field research team! As the airboat quietly drifted towards the gators, one of the players would slowly reach down and then quickly snatch up a gator. A second player helped sit on the gator until Dr. G was able to tape the mouth shut. Then quickly a vial of blood was pulled from the sinus at the top of the head. The animal had a e marked, and length was measured. This one was a small one, only 133 cm. Time zero. One more was captured. Time 15 s enough for tonight. In stealth mode, the two gators were placed into the bed of Jack's pickup truck. Then off to the motel. Dr. G had gotten rooms at the very end of the motel, and as Jack backed into the space in front of the last room, Dr. G and Alex quickly moved the first gator into the bathtub. The second gator was put in the second room. Both had more blood drawn since it was time - 1 hour. Blood was drawn again at t 3, 5, and 7 hours. That last draw was always risky since the sun vas about to rise. Using extreme stealth mode, the three men took the gators back to Lake Apopka. One last blood draw at t-8 hours Exhausted, they headed back to Gainesville. Next weekend, they would do this again at another motel. They needed n-10 samples. But next week they were going to a different lake, a control site. That way they would alternate weeks of data from Lake Apopka and their control site. Pretty much, every weekend in the spring and summer this same stealth operation took place all over northern Florida Dr. Guillette's research was all about Endocrine Disrupting Chemicals. Lake Apopka was laden with DDE (the metabolite of DDT), and he had shown that this was very estrogenic. He now wanted to see whether DDE could also impact other steroids, and this was his experiment on cortisol and allostasis.Explanation / Answer
Inheriting strengths and weaknesses is part of our genetic makeup. Genes are sometimes turned off or on due to external factors which we can have some control over, but at other times little can be done to correct or improve genetic diseases. Beginning at the cellular level a variety of diseases come from mutated genes. Because of genetic differences some bodies need help in gaining or maintaining homeostasis
Peroxisome proliferator-activated receptor (PPAR) is considered a master transcriptional regulator of lipid metabolism and energy homeostasis because typical genes regulated by PPAR are involved in all aspects of fatty acid catabolism (cellular fatty acid uptake, activation of fatty acids, intracellular fatty acid transport, import of fatty acids into the mitochondria, and mitochondrial and peroxisomal fatty acid -oxidation), ketogenesis, as well as gluconeogenesis. PPAR-dependent gene transcription is initiated when a ligand, for example, fatty acids which are released from white adipose tissue during energy deprivation and taken up into tissues during this state, or exogenous ligands such as fibrates, binds to the ligand-binding domain of this transcription factor.
The main bleeding disorders are also enetically inherited.There are several genetic platelet disorders that derive from defects in platelet receptors responsivle for hemostasis.
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