Which of the following is the most likely host target molecule exploited by a pa

Question

Which of the following is the most likely host target molecule exploited by a pathogen if invasion by pathogen is accompanied with inhibition of host cell protein secretion system?

a) Ras

b) Rho

c) Rab

d) ARF6

e) Cdc42

If a bacterial pathogen prevents initiation of actin polymerization in the host cell without entering into the cell then the pathogen must be utilizing trigger mechanism during invasion.

a) True

b) False

If a bacterial pathogen has a molecule mimicking paxillin, which of the following mechanism is likely to be used during host cell invasion?

a) Zipper

b) Trigger

Which of the host cell receptors are typically exploited when pathogens induce their entry into the cell?

a) Integrin

b) Cadherin

c) Toll/Toll-like receptors

d) MHC type 2 receptor

e) Both a and b

NF-?B is a protein complex found in almost all animal cell types and controls transcription of genes involved in immune responses to infection. When cells recognize pathogens, signals generated by pathogen stress induce proteasome-dependent degradation of the inhibitory subunit of the complex, leading to release of stimulatory subunit, which acts as transcription activator for genes required for inflammation. What would you predict for the level of inflammation at the invasion site if a bacterium secretes a toxin that completely inhibits ubiquitin ligase in the cells?

a) Level of inflammation increases

b) Level of inflammation decreases

c) No effect on inflammation regulation

Need explanation for your answer chosen. Thank you!

Explanation / Answer

1)D

2)B

3)A

4)D

5)B

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