Which is statement is TRUE? Phosophorylation of a receptor tyrosine kinase makes
ID: 3508916 • Letter: W
Question
Which is statement is TRUE?
Phosophorylation of a receptor tyrosine kinase makes the receptor a transcription factor which migrates to the nucleus
The Jak-STAT pathway requires a phophorylation step but the receptor tyrosine kinase pathway does not
Gbeta and Ggamma form the extracellular binding pocket for a ligand which activates the G-protein pathway
Prostaglandin production requires the activity of the cyclooxygenase enzyme
G-proteins are active when Galpha is bound to GDP
A.Phosophorylation of a receptor tyrosine kinase makes the receptor a transcription factor which migrates to the nucleus
B.The Jak-STAT pathway requires a phophorylation step but the receptor tyrosine kinase pathway does not
C.Gbeta and Ggamma form the extracellular binding pocket for a ligand which activates the G-protein pathway
D.Prostaglandin production requires the activity of the cyclooxygenase enzyme
E.G-proteins are active when Galpha is bound to GDP
Explanation / Answer
E. G-proteins are active when G alpha is bound to GDP ion
Explanation: The three subunits of heterotrimer G-proteins are G, G, and G subunits. G subunit determines the receptors to which a G-protein trimer binds to . At rest, the G subunit is GDP bound. Activation of G-proteins takes place through exchange of GDP for GTP.
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