201: Case Study writing Assignment #2: Muscles and Nervous Savid is now two days

Question

201: Case Study writing Assignment #2: Muscles and Nervous Savid is now two days post-operative and is recovering in the Surgical Intensive Care Unit. You recall all of the activity that occurred to save his life by treating his malignant hyperthermia. You researched this condition and discovered that it is an inherited disease. While under general anesthesia, the affected person will experience a rapid rise in body temperature and severe muscle contractions. Dr. Hodges drops by to see and says to you, "I was impressed how you handled yourself during a very stressful situation. Good job David 1. David's body temperature rises above normal during the surgery (hyperthermia). How does skeletal muscle tissue contribute to body temperature? During malignant hyperthermia, there is an increased amount of calcium released into the sarcoplasm of skeletal muscle cells. 2. What organelle stores calcium in muscles cells? Describe the events that must occur in the muscle cell before calcium is released from this organelle a. b. Jaw muscle contraction (masseter spasm) is one of the key physical findings seen in David's case of malignant hyperthermia. Explain how calcium functions to cause contraction of a skeletal muscle cell. 3. 4. Dr. Hodges notes that David's exhaled carbon dioxide levels are elevated. List all he metabolic ys that function to synthesize ATP for skeletal muscle contraction. Which of these pathways pathwa produces carbon dioxide as a by-product

Explanation / Answer

1) When skeletal muscles contract, it uses ATP. During ATP use one inorganic phosphate is lost and ATP is converted into ADP. This causes a release in heat energy. Therefore,when much of the skeletal tissue is contracting, heat energy is being given offwhich raises the temperature of the body.

2 a) The main storage site for calcium is the endoplasmic reticulum inmuscle cells, specifically known as the sarcoplasmic reticulum.

2 b) 1.An action potential reaches the synaptic terminal

2.Acetylcholine is released into the synaptic cleft

3.ACh molecules land on receptors on the motor end plate

4.An action potential is generated and travels across the sarcolemmasurface

5.The action potential travels down T-tubules

6.Calcium ions are released into the sarcoplasm

3) Calcium binding to troponin triggers it to change shape and pivot. This action pulls tropomyosin off the actin binding sites for myosin on the thin myofilament. This sets the stage for cross bridge formation. At this point, the myosin heads have already been activated by the hydrolysis of ATP before cross bridges can form.

4) Direct phosphorylation of ADP by creatine phosphate and Anaerobic metabolism

Aerobic metabolism: has the highest yield of ATP (32 molecule) and produces CO2.

Related Questions

Navigate

• Browse (All)
• Browse 2
• Subjects

---

---

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.