11. How is the Time of repolarization related to the slope of the repolarization

Question

11. How is the Time of repolarization related to the slope of the repolarization phase? What does this change in the Time of repolarization mean for the length of the entire action potential?

-Why does increasing gK+ alter the time of repolarization and slope in the direction it does (hint: What is happening at the cellular level; What is the relationship between gK+ and IK+)?

-There are drugs that act as selective blockers to voltage-gated K+ channels. What will happen to excitable cell signaling rates in patients exposed to these drugs, explain your answer?

Explanation / Answer

Ans 1 Time of repolarization is directly related to the depolarising phase.This change in time means that the cell potential become positive the sodium channels are open and the potassium channels bring down and exit from the cell .An action potential starts propagating as the cells are in the depolarizing phase and conducts the message by altering between open and open ion channels.

The increasing k+ alters the time of repolarization because more voltage gakted k + will efflux out from the membrane but with slower kinetics as compared to Na channels thus increases the time of repolarization. And the slope of the graph will decrease .At the cellular level the k channels will exit out and sodium channel will enter in the cell.

3.Drugs that acts as selective blockers to voltage gated k channels can increase the excitability of cell signalling rates. The patient has an increase rate of transmission of cell signalling in excitable cells .These drugs will inhibit the depolarization phase of the cell.

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