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these questions are regarding the book psychopharmacology by Jerrold Meyer and L

ID: 3485005 • Letter: T

Question

these questions are regarding the book psychopharmacology by Jerrold Meyer and Linda Quenzer

8. In Koob and LeMoal’s transition to the dark side of addiction, there is a progressive down-regulation of activity in the reward system involving _________; and a gradual recruitment of the anti-reward system involving ________?

a. dopamine, GABA & opioids; CRF & norepinephrine

b. CRF & norepinephrine; dopamine, GABA & opioids

c. 5-HT & norepinephrine; dopamine, GABA & opioids

d. dopamine, GABA & opioids; 5-HT & norepinephrine

e. dopamine, 5-HT & opioids; CRF and GABA

9. According to the comprehensive Biopsychosocial model of addiction, which of the following is NOT a factor that increases compulsive drug seeking and drug use?

a. Positive reinforcing effects of drugs (euphoria, increased mood)

b. Negative reinforcing effects of drugs to avoid withdrawal (reduce anxiety & depression)

c. Stimuli that are conditioned to the drugs effects (drug associated cues)

d. Psychosocial and biological risk factors (stress, genetics).

e. Peer pressure

10. According to the disease (medical) model of drug addiction, which of the following leads to a loss of control, and compulsive drug seeking and drug use?

a. Inherited susceptibility

b. Altered brain function

c. Lack of will power

d. Both a and b, but not c

e. All of the above

11. Which of the following neurotransmitter systems is involved in the cellular and behavioral effects of ethanol?

a. Glutamate

b. GABA

c. Dopamine

d. Opioids

e. All of the above

Explanation / Answer

8). a. dopamine, GABA & opioids; CRF & norepinephrine

Development of negative emotional state in addiction stems from the decreased reward pathway and increased anti-reward pathway. The downregulation of reward system mainly involves the dopamine, gamma amino butyric acid and opioids. The anti-reward system includes the corticotropin-releasing factor or CRF, neuropeptide Y norepinephrine, and nociceptin.