1. In my research, I found that the levels of “gonadotropins” in the body are cr
ID: 3484276 • Letter: 1
Question
1. In my research, I found that the levels of “gonadotropins” in the body are critical to understanding how the drugs Clomid and Ortho Tri-Cyclen work. What are gonadotropins? What role do they play in fertility? there are two types of gonadotropins in the body: follicle stimulating hormone (FSH) and luteinizing hormone (LH). Both are produced by the pituitary gland to trigger the production of sex hormones. Gonadotropins help create eggs and sperm along with male and female physical characteristics, such as voice, muscle, hair and breast development. 2. Some of the references talk about how “negative feedback” is involved in understanding how these drugs work. Can you explain what is meant by negative feedback? 3. My doctor told me that birth control pills contain small amounts of estrogen and progesterone, and these hormones prevent me from ovulating. I don’t understand how giving me these hormones in a pill would prevent me from ovulating. I assume that it has something to do with the levels of the gonadotropins that I asked about earlier. Can you explain this to me? 4. In the information about Ortho Tri-Cyclen, it mentions that the hormones in the pill make cervical mucus thicker and stickier. Does this happen during my natural cycle? How are estrogen and progesterone involved in this process? 5. My doctor also explained that birth control pills “trick the body into thinking it is pregnant.” She explained that women do not normally ovulate when they are pregnant. Can you explain to me why a pregnant woman does not ovulate? How is this related to how the birth control pill works? 6. My doctor explained that Clomid works by “tricking the brain into thinking that estrogen levels in the body are low.” She explained that this is what leads to the extra stimulation of the ovaries to encourage eggs to be released. One of the references for Clomid said this happens because there is less negative feedback. Can you explain to me how this “trick” and the decreased negative feedback are related? Why would these factors lead to the stimulation of the ovaries? 7. My doctor told me that if I take Clomid, I would be taking it on days five through nine of my normal menstrual cycle. She explained that this is when it will have the greatest chance of stimulating the ovaries. What is going on during this part of the menstrual cycle that makes it the best time to take this drug? 8. I read an article that mentioned that women on Clomid may be more likely to get pregnant with twins, triplets, or more! The article said that normally there is a dominant follicle that releases a single egg, but Clomid can potentially make lots of follicles release an egg in a given month. How does Clomid do that?
Explanation / Answer
1.
Gonadotropins are included with the structures of fertility and reproduction. In particular, ladies have gonadotropins situated at the ovaries, which help with egg generation and ovulation. The two gonadotropins incorporate FSH (follicle stimulating hormone) which fortifies the follicles in the ovaries, and LH (luteinizing hormone) which help with ovulation. Whenever variations from the norm happen in both of these hormones, at that point infertility could come about.
2.
A straightforward method to consider "negative feedback" is thinking about the thermostat in your home. On the off chance that the thermostat is set to 72 degrees, and the house progresses toward becoming warmer than 72, the aerating and cooling will kick on. Nonetheless, on the off chance that it winds up plainly cooler at that point 72, either the warmth will kick on, or the thermostat won't turn on. Negative feedback is your body's method for keeping everything regulated and in harmony.
3.
The birth control contains small amounts of estrogen and progesterone to stabilize a woman’s hormone levels and prevent estrogen from getting too high mid-cycle. When a higher level of progesterone is present, it prevents secretions of FSH and LH. This means that no egg develops and no ovulation occurs and the menstrual
the cycle continues without a minimal risk of pregnancy.
4.
Ordinarily, if a treated egg were to append to the covering of the uterus, the coating would be smoother and more slender. The egg would have the capacity to join the divider, prompting a pregnancy. Notwithstanding, when progesterone and estrogen are available, the cervical bodily fluid thickens so the sperm can't achieve the egg and makes the coating of the uterus thicker to forestall preparation of the egg.
5.
In an ordinary pregnancy, when the treated egg appends to the uterus, the corpus luteum, which is situated in the ovary, keeps on delivering progesterone required to keep the egg implanted. Because of the expansion of the progesterone in the bloodstream, it keeps the arrival of FSH and LH averting further ovulation amid the pregnancy. This guarantees a moment egg doesn't progress toward becoming prepared later after the principal egg is. When taking conception prevention, the expanded levels of progesterone are kept up which obstructs the arrival of FSH and LH, like that of a pregnancy.
6.
Normally, the pituitary gland will release LH and FSH, which would stimulate follicular growth in the ovaries, thus starting the ovulation cycle. Clomid blocks estrogen receptors “tricking” the brain to think estrogen is low and release more. This blocks the negative feedback of estrogen, leaving FSH to stimulate the ovarian follicles into releasing an egg.
7.
The doctor is more than likely recommending to take Clomid during days 5-9 since normal ovulation is typically between days 14-16.
8.
Typically, ladies have a 3% possibility of conceiving twins normally. There are different circumstances which can expand a lady's hazard, for example, age and genetics. The possibility of conceiving twins while expending Clomid is around 8%. The motivation behind why Clomid builds your odds of conceiving products is that your body is delivering additional hormones which fortify follicles to develop and develop. This builds the generation of estrogen which can the arrival of more than one egg. People that do have twins, will more than likely have congenial twins (twin that doesn't resemble the other alike).
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