A hormone called thyroid-stimulating hormone (TSH) is secreted by the anterior p

Question

A hormone called thyroid-stimulating hormone (TSH) is secreted by the anterior pituitary gland and acts on the thyroid gland to increase the secretion of thyroid hormones. Thyroid hormones on the other hand, have a negative-feedback effect on TSH secretion. For a person having normal thyroid function, the rate at which TSH and thyroid hormones are secreted remains within a normal range of concentrations. However, in some people the immune system begins to produce an abnormal substance that functions like TSH. Predict what that substance will do to the rate of thyroid stimulating hormone secretion and the rate of thyroid hormone secretion.

Explanation / Answer

The normal range of TSH levels is 0.4 to 4.0 milli-international units per liter and for Thyroid hormones the range will be Total T4- 4.5 to 11.5 ug/dl, free T4 0.8 to 2.8 ng/do, total T3 75 to 200 ng/dl.

In Graves diseases the abnormal antibodies are produced that mimic like TSH. The antibodies named as TSH receptor activating antibodies due to a genetic cause. Human leukocyte antigen DR appears to play a role. It will activate the TSH receptor from thyroid gland and will produce more Thyroid hormones results in a disease called Goiter and Hyperthyroidism.

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