1. Medical grade silicone elastomers have been used in small joint arthroplasty
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Question
1. Medical grade silicone elastomers have been used in small joint arthroplasty for the treatment of arthritis of small joints and foot. H materials elicit some degree of ho of the hand, wrist, owever, recently it is found that instead of being inert, these st response, which includes fibrous caulation. Please explain how fibrous encapsulatio n may affect the function of the silicone implants both positively and negatively. (6 poin Hand & Wrist 2. True or False: The tissue response at a wound site following implantation of a non-degradable biomaterial is the same when compared to a simple lesion such as a stab wound at the same tissue location. Please explain your answer. (5 points)Explanation / Answer
Medical grade silicon:
It was used to prepare outer surface of internal implants for joint arthroplasty.
Host response:
The body response to implanted device is called host response. If the implants are not interact proplerly with body tissues it will cause complication such as pain, inflammation,infection,etc.
Silicon implant induced coagulation:
To prevent the blood loss, body will start to do coagulation process by protein synthesis after silocon prosthetic implantation. Also protein synthesis induce or activate the immune system.
Silicon implant encapsulation:
Activated immune system will start to attack the implant by inflammatory process because of the implant is considered foreign material.
Chronic inflammation leads to deposits of FIBRINOGEN and PLATELETS on around the silicon implant. This is called encapsulation.
Fighting against foreign material by inflammatory blood cells fibrinigen and PLATELETS forming encapsulation around implant.
As the body is considered the implant as foreign material, it is attacking and encapsulating the implant. The intention of whole process is to remove the implant from the body.
Management for encapsulation:
1) Treating microbic invasion is the initial treatment for encapsulation.
2) If microbic invasion is very deep to the encapsulation then remove the entire implant/arthroplasty is next level treatment.
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