1. The mother produces antibodies from B cells that have become plasma cells. Ho
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1. The mother produces antibodies from B cells that have become plasma cells. How is this accomplished? 2. The antibody from mother is transferred to the baby via breastmilk. The baby is born with only innate immunity. Describe the baby's innate immunity. 3. The antibody from mother then “primes" the baby's adaptive immune system. Which cell is receiving this antibody and what is done with adaptive immunity next? 4. T cells in the baby participate in the production of antibodies. Describe the system of MHC , peptide and T-cell receptor (TCR) in the three-different cell type that participate in antibody production. 5. CD8 Killer T cells and Natural Killer cells (NK cells) both have the ability to induce apoptosis in most cells of the body. What distinguishes these two cells and their killing abilities 6. Cancer is the result of the escape from the MHC-peptide/TCR surveillance system. Give an exampleExplanation / Answer
1-When the memory B cell is activates by antigen,it proliferate and differentiate into antibody secreting effector cells. Though many die after sevral days but some may get accumulated in bone marrow and continue to secrete antibodies in blood.
2- The feotus and the newborn faces a complex set of immnological demands including protection against infections,avoidance of harmful inflammatory immune responses that can lead to pre term delivery and balancing the transition from a sterile intra uterine environment to the world that is rich in foreign antigen. These demands innate immune systems that is biased against the production of pro-inflammatory cytokines. These biases protects the newborns with infections and impairs responses to many vaccines.
3- tha newborn's immune system grows fast at birth by expose primarily to the intestinal microflora which is normally obtained from mother at or after birth.
4- when TCR is engaged with antigenic peptide and MHC II then T- lymphocytes is activated through signal transductions, that is a series of biochemical events medicated by associated enzymes and many more.
5- Most potential CTL express a recptor for FasL designate Fas. When cytotoxic T cell is recognised they bind to their target and produces more and more FasL to their surface. This binds with Fas on the surface of target cell leading to the death by apoptosis.
The natural killer cells secret perforine which form pores in the cell membrane of the target cell leading to either apoptosis or osmotic cell lysis
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