A 39-year-old man presents with a 6-month history of severe headaches and pain o

Question

A 39-year-old man presents with a 6-month history of severe headaches and pain of the hands upon exposure to cold. Over the past 3 months, he has noticed progressive difficulty in swallowing solid food. Physical examination reveals smooth and tight skin over the face and fingers. The serologic test for anti–Scl-70 (antitopoisomerase) is positive. Which of the following vascular changes accounts for this patient's headaches and hand pain?

Options:

A) Smooth muscle cell proliferetion and lipid deposition

B) Intimal thicking and fibrosis

C) Vasculitis and fibrinoid necrosis

D) Acute inflammation of the intima

E) Giant cell granulomatous inflammation

Explanation / Answer

Above is the case of scleroderma as serologic test is positive and in such a disease there is hardening of skin due to accumulation of collagen. Here phenomenon of fibrinoblast also happened. Hence correct option is B that is intimal thickening and fibrosis.

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