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why is this the correct answer???? 15. Imagine a cell with a resting membrane po

ID: 3479111 • Letter: W

Question

why is this the correct answer????

15. Imagine a cell with a resting membrane potential of -60 mV. If the uptake of an cationic drug ("D*") is limited to facilitated diffusion, depolarizing the membrane potential from -60 mV to -40 mV might be reasonably expected to have which of the following effects a. increase the rate of uptake of the drug (but have no effect on steady-state accumulation) b. decrease the rate of uptake of the drug (but have no effect on steady-state accumulation) c. decrease steady-state accumulation of the drug d. increase steady-state accumulation of the drug e. no effect on either the rate or steady-state accumulation of the drug

Explanation / Answer

Answer is A as due to depolarisation, channels get open and drug enters inside easily leading to increase in rste of uptake of drug.