11. (25 points) For each of the following drugs, sta skeletal or smooth muscle c
ID: 3478930 • Letter: 1
Question
11. (25 points) For each of the following drugs, sta skeletal or smooth muscle contraction/relaxatio rgets RE n pathway Prazosin-alpha adrenergic receptor antagonist Ziconotide-inhibits voltage gated calcium channels a-Bungarotoxin-muscarinic Ach-R antagonist Excess Nicotine Dantrolene- Ryanodine receptor inhibitor KT5926-myosin light chain kinase inhibitor Blebbistatin-inhibits troponin Oligomycin-inhibits ATP synthesis Thapsigargin-inhibits SERCA Xestopongin C-inhibits IP3 receptor Digitalis - inhibits Nat/k+ ATPase pump Genistein - blocks potassium leak channelsExplanation / Answer
Prazosin target is alpha andrenergic receptors. It helps in the contraction of the smooth muscles.
Alpha bungarotoxin target is nicotinic acetylcholine receptor. It causes immediate paralysis and death of an individual.
Dantrolene target is ryanodine receptors. It inhibits the release of calcium ions from sarcoplasmic reticulum.
Excess nicotine targets peripheral and central nervous system.
KT5926 is a potent inhibitor of myosin light chain. It inhibits calcium/calmodulin dependent and independent smooth muscle myosin light cahin functions.
Blebbistatin is an inhibitor of myosin II. It inbitis the cardiac muscle and skeletal muscles.
Oligomysin is an inhibitor of ATP synthase. It blocks the proton channel necessary for ATP synthesis.
Xestospongin C is an potent inhibitor of IP3 receptor.
Thapsigargin is an inhibitor of sarco/endoplasmic reticulum Ca2+ ATPase (SERCA). It is a promoter of tumor cells.
Genistein is an angiogenesis inhibitor.
Digitalis is an sodium potassium ATPase inhibitor. It is used during cardiac dysfunction. It is used to increase cardiac muscles contractility.
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