6. How might the administration of fibrinogen concentrate reduce the amount of u

Question

6. How might the administration of fibrinogen concentrate reduce the amount of uncontrolled bleeding in this patient? (2 pts) Although our local poison control centre had no knowledge of caterpillar envenomation, they facilitated contact with clinicians from Brazil, who recommended immediate administration of a locally produced antivenin. We made arrangements to obtain the antivenin from Brazil, which took 48 hours to arrive. 7. What class of macromolecule is antivenin? (2 pts). Our patient's condition remained stable for the initial 48 hours. On her third day in hospital (10th day after envenomation), alveolar hemorrhage, anuric acute kidney injury and hemodynamic instability developed. She received mechanical ventilation, vasoactive agents and continuous renal replacement therapy. There was evidence of progressive microangiopathic hemolytic anemia (loss of red blood cells), consumptive thrombocytopenia (loss of platelets) and disseminated intravascular coagulation. We received the antivenin from Brazil and administered it on the 10th day after envenomation (third day in hospital); however, our patient's organ dysfunction progressed, and she died of multiorgan failure later that day.

Explanation / Answer

7. Since fibrinogen is a part of the clotting pathway and is a vital part , the administration of fibrinogen will increase the concentration in the blood, and lead to the formation of clots wherever bleeding is seen.

8. Antivenin is made from antibodies. Since antibodies come under the category of proteins, antivenin also comes under the same category of proteins.

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