Lambert-Eaton Myasthenic syndrome (LEMS) is a rare autoimmune disorder character

Question

Lambert-Eaton Myasthenic syndrome (LEMS) is a rare autoimmune disorder characterized by painless muscle weakness of the limbs. It is the result of an autoimmune reaction in which antibodies are formed against presynaptic voltage-gated calcium channels. Describe the importance of calcium channels in the neural transmission. What would be the result of the calcium deprivation. Specifically how would this effect neurotransmitters and their ability to be exocytosed upon action potential? Lambert-Eaton Myasthenic syndrome (LEMS) is a rare autoimmune disorder characterized by painless muscle weakness of the limbs. It is the result of an autoimmune reaction in which antibodies are formed against presynaptic voltage-gated calcium channels. Describe the importance of calcium channels in the neural transmission. What would be the result of the calcium deprivation. Specifically how would this effect neurotransmitters and their ability to be exocytosed upon action potential?

Explanation / Answer

LEMS is a presynaptic disorder of neuromuscular transmission. In this disorder antibodies are formed against voltage gated calcium channels. Calcium channels are needed when synaptic vesicles in presynaptic neuron releases neurotransmitters which binds to post synaptic neuron. Absence or deprivation of calcium channels leads to absence of chemical transmission. The absence of calcium gated channels will hinder the release of neurotransmitters from the synaptic vesicles.

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