Lambert-Eaton Myasthenic syndrome (LEMS) is a rare autoimmune disorder character
ID: 3477377 • Letter: L
Question
Lambert-Eaton Myasthenic syndrome (LEMS) is a rare autoimmune disorder characterized by painless muscle weakness of the limbs. It is the result of an autoimmune reaction in which antibodies are formed against presynaptic voltage-gated calcium channels. Describe the importance of calcium channels in the neural transmission. What would be the result of the calcium deprivation. Specifically how would this effect neurotransmitters and their ability to be exocytosed upon action potential? Lambert-Eaton Myasthenic syndrome (LEMS) is a rare autoimmune disorder characterized by painless muscle weakness of the limbs. It is the result of an autoimmune reaction in which antibodies are formed against presynaptic voltage-gated calcium channels. Describe the importance of calcium channels in the neural transmission. What would be the result of the calcium deprivation. Specifically how would this effect neurotransmitters and their ability to be exocytosed upon action potential?Explanation / Answer
the Voltage-gated calcium (Ca2+) channels are the key transducers of membrane potential which changes into intracellular Ca2+ transients that causes initiatiation to many physiological events. There are around ten members of voltage-gated Ca2+ channel family in the mammals, which serve different roles in cellular signal transduction.
In the muscle cells, the nerve endings release the calcium ions, which binds to activator proteins. This activator proteins starts the complex process of the muscle contraction and allows our muscles to move. Without calcium, our muscles would not be able to contract and relax.
the Low-voltage-activated (LVA) T-type Ca2 + channels differ from their high-voltage-activated (HVA) homologues by the unique biophysical properties. Hence, HVA channels convert the action potentials into the intracellular Ca2 + elevations, the T-type channels control Ca2 + entry during a small depolarizations around resting membrane potential. They play an major role in the electrical activities by generating a low-threshold burst discharges that occur during different physiological and pathological forms of neuronal rhythmogenesis. In additionto this, they also mediate a previously nonrecognized function in control of the synaptic transmission where they directly trigger release of neurotransmitters which were at rest.
Related Questions
Navigate
Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.