y cellular processes are regulated when ligands bind to G-protein coupled recept

Question

y cellular processes are regulated when ligands bind to G-protein coupled receptors leading to a change in cell activity. Put the following steps i correct numbers in each blank. The first and last steps have already been numbered. (3 pts) Man order for the Gs sti imulatory) pathway by writing the Ligand binds to the G-protein coupled receptor Alpha subunit of the G-protein dissociates from the Beta and Gamma Subunits Production of cAMP Alpha subunit of the G-protein binds to GTP 2Alpha subunit of the G-protein releases GDP . Activation of Protein Kinase A Alpha subunit of the G-protein binds to and activates Adenylyl Cyclase Cellular Response 2 8

Explanation / Answer

1. Ligand binds to GPCR

2. Alpha subunit releases GDP

3. Alpha subunit binds to GTP

4. Alpha subunit dissociates from the beta and gamma subunits

5. Alpha subnit binds to and activates adenyly cyclase

6. Production of cAMP

7. Activation of Protein Kinase A

8. Cellular response

cAMP cannot be synthesized until adenyl cyclase has been activated, therefore it must be activated before production of cAMP must begin.

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