3.10 Melanoma treatment. An experiment evaluated the use of genetically engi- ne

Question

3.10 Melanoma treatment. An experiment evaluated the use of genetically engi- neered white blood cells in the treatment of patients with melanoma.y Patients were divided into three cohorts. Patient cohort 1 received genetically engi. neered lymphocytes that were cultured ex vivo for 19 days. Cohort 2 received cells that were cultured for between 6 and 9 days. Cohort 3 received cells that were generated by a second rapid expansion performing after 8 to 9 days. Cel doubling times were as follows. Cohort 18.7 11.9 10.0 Cohort 21.4 1.0 1.3 1.0 1.3 2.0 0.6 0.8 0.7 0.91.9 Cohort 3 0.9 3.3 1.2 1.1

Explanation / Answer

Random error occurs because the estimates we produce are based on samples, and samples may not accurately reflect what is really going on in the population at large.

Confidence intervals only address random error, and do not take into account known or unknown biases or confounding, which occurs in epidemiologic studies.

Answer: Option A

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