4- A clinical microbiology laboratory compared the frequency of isolation of DNA

Question

4- A clinical microbiology laboratory compared the frequency of isolation of DNA hybridization probe to a culture method for the sexually transmitted bacterium Neisseria gonorrhaeae. The frequency of isolation from clinical specimens was historically 10%. The lab ran 100 split samples, and the results are presented in the table below. (20 pts) Table. Comparison of the Distribution of Negative and Positive Results for the DNA Probe and Culture Methods. Culture Results Positive Negative DNA Probe Results Positive Negative a) Calculate the positive predictive value? b) Calculate the negative predictive value?

Explanation / Answer

A) positive predictive value = A/(A + B) * 100

= 9/(9 + 2) * 100 = 9/11 * 100 = 82%

B) Negative predictive value = D/(D + C) * 100

= 88/(1 + 88) * 100 = 88/89 * 100 = 98.88%

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