Which of the following clinical tests is(are) associated with skin sensitization

Question

Which of the following clinical tests is(are) associated with skin sensitization, a.k.a. allergic contact dermatitis (ACD)?

I. Forearm Controlled Application Test (FCAT)

II. 3-patch test (3-PAT)

III. Human Repeat Insult Patch Test (HRIPT)

I only

III only

I and II

II and III

I, II and III

Which of the following is(are) preclinical methods for estimating risk of irritant contact dermatitis (ICD)?

I. Murine Local Lymph Node Assay (LLNA)

II. Direct Peptide Reactivity Assay (DPRA)

III. Il-1 release in cultured human keratinocytes, e.g. EpiDerm system

I only

III only

I and II

II and III

I, II and III

Which of the following preclinical assays would be acceptable for cosmetic product development according to the principles of the 7th Amendment to the EU Cosmetics Directive?

I. Direct Peptide Reactivity Assay (DPRA)

II.  Il-1 release from cultured human keratinocytes

III. Murine Local Lymph Node Assay (LLNA)

I only

III only

I and II

II and III

I, II and III

What ultrasonic frequencies have been associated with the largest preclinical demonstrations of an increase skin permeability for hydrophilic solutes?

10-100 Hz

16-20 kHz

1-3 Mhz

10-16 MHz

1-3 GHz

I only

III only

I and II

II and III

I, II and III

Explanation / Answer

Q. 1)

3-Patch Test (3-PAT) and Human Repeat Insult Patch Test (HRIPT) are associated with skin sensitization.

Hence correct option is (d) .

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