Suppose you have enough funds to conduct a small pilot study of the effect of a

Question

Suppose you have enough funds to conduct a small pilot study of the effect of a new anti-inflammatory drug on blood pressure. You collect 40 hypertensive participants (systolic blood pressure > 140 mmHg) for your study, and measure their SBP as a baseline for the study. You then require that each participant take one pill each morning for 30 days, and then measure their SBP again. What test should you do if you are interested in determining whether this anti-inflammatory drug significantly lowered SBP over the course of 30 days? and why that test? how do we determine it is the apropritate test?

Explanation / Answer

We should conduct a paired sample T test.

The paired sample t-test is a statistical procedure used to determine whether the mean difference between two sets of observations is zero. In a paired sample t-test, each subject or entity is measured twice, resulting in pairs of observations.Here we are measuring the SBP of a sample of hypertensive participants before and after taking one-pill each morning, and analyze the differences using a paired sample t-test.

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