A) a woman has an X chromosome with a recessive disease allele. Can she pass the

Question

A) a woman has an X chromosome with a recessive disease allele. Can she pass the disease allele to her sons or daughters of both?
B) a man has an X chromosome with recessive desease allele. Can he pass the disease to his sons or daughters or both? A) a woman has an X chromosome with a recessive disease allele. Can she pass the disease allele to her sons or daughters of both?
B) a man has an X chromosome with recessive desease allele. Can he pass the disease to his sons or daughters or both?
B) a man has an X chromosome with recessive desease allele. Can he pass the disease to his sons or daughters or both?

Explanation / Answer

In X linked recessive inheritance two copies of a disease allele on the X chromosome are required for an individual with two X chromosomes (a female) to be affected with an X-linked recessive disease.

A) a woman has an X chromosome with a recessive disease allele. Can she pass the disease allele to her sons or daughters of both?

For a carrier female, with each pregnancy there is a one in two (50%) chance her sons will inherit the disease allele and a one in two (50%) chance her daughters will be carriers.

B) a man has an X chromosome with recessive disease allele. Can he pass the disease to his sons or daughters or both?

Affected males transmit the disease allele to all of their daughters, who are then carriers, but to none of their sons.

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