A. Chromosomal alterations often result in spontaneous abortion. Why? B. Inversi

Question

A. Chromosomal alterations often result in spontaneous abortion. Why? B. Inversion or translocation heterozygotes have difficulty in producing gametes that function properly. Is there a way that an inversion heterozygote could produce functional gametes? A. Chromosomal alterations often result in spontaneous abortion. Why? B. Inversion or translocation heterozygotes have difficulty in producing gametes that function properly. Is there a way that an inversion heterozygote could produce functional gametes? B. Inversion or translocation heterozygotes have difficulty in producing gametes that function properly. Is there a way that an inversion heterozygote could produce functional gametes?

Explanation / Answer

Ques-1: Chromosomal alterations often result in spontaneous abortion. Why?

Spontaneous abortion: It defined as a miscarriage associated with spontaneous failure of a fetus due to chromosomal alterations often result in spontaneous abortion before twentieth week during pregnancy. These chromosomal alterations are leading to monosomy that produces cells with 45 chromosomes instead of 46 chromosomes in the cells and it often referred as aneuploidy. Turner syndrome is the result of autosomal monosomy leading to miscarriage in early pregnancy followed by spontaneous abortion due to lethal effects.

Ques-2:

Yes, if the heterozygote that has inversion in chromosome and other chromosome has no inversion then there is a chance of 50% functional gametes by passing them for fertilization. On the other hand, if the inversion of the genome involves no change in coding regions (silent mutation) are leading to normal functioning of gametes

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