Fill in missing cells and calculate sensitivity and specificity for this example

Question

Fill in missing cells and calculate sensitivity and specificity for this example: The goal of the SomeWhereVille Department of Health (SDOH) is to reduce morbidity caused by Susser Syndrome (SS). There is reason to believe that if a new treatment made by DoseEmAll Pharmaceuticals is begun before clinical symptoms first appear, the treatment can prevent irreversible neurological damage and slow down the progression of disease accompanied by worsening of the neurological symptoms. A screening test is identified (SussStat), and compared to a clinician's diagnosis. a. Calculate the sensitivity, specificity, PPV, and NPV and interpret. What is a consequence if SussStat has a low sensitivity? Using the sensitivity and specificity measures you calculated in Question 2 above, calculate what the PPV would be if you screen the total population of SomeWhereVille where you estimate the prevalence of Susser Syndrome to be only 1%.

Explanation / Answer

(1)

Sensitivity = 240/340 = 0.706

Specificity = 700/1000 = 0.7

Disease No Disease Total Positive 240 100 340 Negative 60 600 660 Total 300 700 1000

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